Scientists increased the production of stem cells in the adult brain of mice using the method of editing the CRISPR/CAS9 genome, which received the Nobel Prize.
Researchers from various Universities in the United States have found ways to preserve the stem cells of the brain with young and active in old age by making adjustments to the genes. In particular, the experiment was carried out with the involvement of young and elderly mice.
Researchers who have made changes to the work of 23 thousand genes of mice using the method of editing the CRISPR/CAS9 genome, found that 300 different genes affecting the metabolism of mice play a role in the aging of neuronal stem cells.
Scientists drew attention to the fact that genes in the cells of the subventricular zone of the brain of young and old mice are especially important for the production of stem cells. One of these genes, SLC2A4, reduces the amount of glucose consumption with cells. When his work was broken, the cells began to consume less glucose and began to multiply better.
The study is published in the journal “Nature”.