Scientists from Canada and Spain identified factors that influence the survival of patients with the severe form of COVID-19 flow. According to their data, these are indicators of blood test indicators, the main of which is the level of specific antibodies against the SARS-COV-2 spike protein causing COVID-19. Such information is contained in the article published in the Journal of Internal Medicine magazine, the quotes of which brings RBC.
The conclusion about the protectedness of a person from coronavirus, according to the publication, can be made on the basis of three indicators of blood test indicators: the level of specific antibodies to counter the specific parts of the virus or antigens, antigenias (total antigens), as well as the amount of RNA of the virus in the blood. At the same time, according to scientists, it still remained unclear which one is to be key to key when determining the likelihood of death.
Specific antibodies to the Square protein COVID-19 can block the replication of the virus. Antigenia reflects the total number of identifiable by the body as antigen alien substances. In turn, the number of viral RNA indicates how much virus is currently contained in the body.
For the study, the results of analyzes 92 adult patients were used to be treated at the Rio Ortega University Hospital and the Clinical Hospital of Valladolid, at the Gregorio Maragoron Hospital and the Madrid University Hospital of Prince Asturia. All of them were in medical facilities from March 16 to April 15, 2020 – in the first wave of Pandemic, and had a confirmed diagnosis of COVID-19, which they were set with the help of PCR test. Also, all patients took blood for analysis for the first day of treatment.
In the framework of the study, the specialists accounted for an antibody profile (first of all, IgM and IgG) against the COVID-19 S-protein and evaluated the dependence between their levels, the concentration of the RNA of the virus and the presence in the plasma of the nucleoprotein (N) protein of this infection in the plasma. The plasma also evaluated the indicator of the total number of antigens to the protein N and studied how it affects the risk of mortality.
“Conclusions: Low levels of antibodies to the SARS-COV-2 virus S-protein predict mortality at critical COVID-19,” the Journal of Internal Medicine website says. The results of the study confirm that “these antibodies contribute to the prevention of SARS-COV-2 systematic distribution, scientists also noticed.
Research authors believe that their conclusions will help determine the optimal level of antibodies, for each critical patient with coronavirus.